Pharmaceutical packaging demands materials that preserve drug stability, prevent contamination, and comply with global regulatory standards. Among the most reliable elastomers used for vial and bottle sealing is the Bromobutyl Rubber Closure. Known for its exceptional barrier properties and chemical resistance, bromobutyl rubber has become the preferred choice for injectable and lyophilized drug packaging.
A well-engineered bromobutyl closure ensures airtight sealing, compatibility with sterilization, and long-term protection of sensitive formulations.
A Bromobutyl Rubber Closure is an elastomeric stopper made from brominated isobutylene-isoprene rubber (BIIR). This material is specifically selected for pharmaceutical use due to its:
These properties make bromobutyl closures ideal for maintaining sterility and drug efficacy.
1. Superior Moisture Barrier
Bromobutyl rubber provides one of the lowest moisture permeability rates among elastomers, which is crucial for protecting lyophilized and hygroscopic drugs.
2. Chemical Inertness
It does not react with active pharmaceutical ingredients, ensuring formulation stability over time.
3. Excellent Sealing & Resealing
The material allows repeated needle penetration without fragmentation, maintaining container-closure integrity.
4. Sterilization Resistance
Bromobutyl closures withstand multiple sterilization cycles without losing mechanical properties.
Bromobutyl closures are widely used in:
Their compatibility with glass and plastic vial systems makes them suitable for automated filling and sealing lines.
A high-quality bromobutyl rubber closure should offer:
These characteristics are essential for meeting pharmacopeial and regulatory expectations.
At Sonata Rubber, bromobutyl rubber closures are manufactured using FDA-compliant elastomer formulations under controlled cleanroom conditions.
Our closures are designed for:
Each batch is tested for:
Standard sizes such as 13 mm, 20 mm, and 32 mm are available, along with customized options for specialized pharmaceutical needs.
Bromobutyl closures produced by Sonata Rubber adhere to:
This ensures consistent performance in highly regulated pharmaceutical environments.
A Bromobutyl Rubber Closure is a critical component in ensuring the safety, sterility, and stability of injectable and lyophilized drugs. Its superior barrier properties, chemical resistance, and resealability make it the preferred choice for modern pharmaceutical packaging.
With advanced manufacturing capabilities and strict quality control, Sonata Rubber provides dependable bromobutyl closures that meet global pharmaceutical requirements.
For technical specifications or bulk requirements, you can connect with the Sonata Rubber team for assistance.
Sonata Rubber Pvt. Ltd. is a leading manufacturer of Rubber Stoppers in Mumbai. We are a trusted and preferred partner across the global pharmaceutical industry.
Sonata Rubber is a leading Manufacturer and Supplier of Antibiotic Rubber Stoppers in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
Sonata Rubber is a leading Manufacturer and Supplier of Lyophilization Rubber Stoppers in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
Sonata Rubber is a leading Manufacturer and Supplier of Large Volume Parenterals Rubber Stoppers in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
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Sonata Rubber is a leading Manufacturer and Supplier of Liquid Injectable Stopper in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
Sonata Rubber is a leading Elastomer Manufacturers in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
Sonata Rubber is a leading Manufacturer and Supplier of Plastic Induction Sealing Wad Caps in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
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Sonata Rubber is a leading Manufacturer and Supplier of Rubber Components in Mumbai, Navi Mumbai, Thane, Ahmedabad, Ahmednagar, Ajmer, Amravati, Amritsar, Aurangabad, Bangalore, Beed, Belgaum, Bharuch, Bhavnagar, Bhopal, Bhubaneswar, Calicut, Chandigarh, Chandrapur, Chennai, Coimbatore, Cuttack, Daman, Delhi, Dhule, Ernakulam, Erode, Gangtok, Ghaziabad, Goa, Hubli, Hyderabad, Indore, Jaipur, Jalgaon, Jamshedpur, Jodhpur, Kolhapur, Kolkata, Lucknow, Ludhiana, Madurai, Agra, Mysore, Nagpur, Nashik, Noida, Patna, Pondicherry, Pune, Raipur, Rajkot, Salem, Satara, Secunderabad, Shimla, Sikkim, Silvassa, Solapur, Srinagar, Surat, Udaipur, Vadodara, Valsad, Vellore, Vijayawada, Visakhapatnam.
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